Publikationen im NUM

Hier finden Sie eine Liste der Publikationen, die im Zusammenhang mit dem Netzwerk Universitätsmedizin in der ersten und zweiten Förderphase entstanden sind.

M. Lehmann, K. Allers, C. Heldt, J. Meinhardt, F. Schmidt and e. a. Rodriguez-Sillke, "Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8(+) T cells", Mucosal Immunol, vol. 14, pp. 1381—1392, 2021.
M. Lehmann, K. Allers, C. Heldt and et al, "Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells", Mucosal Immunol, pp. 1-12, 2021.
DOI:10.1038/s41385-021-00437-z
J. Barros-Martins, S. I. Hammerschmidt and A. Cossmann, "Humoral and cellular immune response against SARS-CoV-2 variants following heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination", MedRxiv, 2021.
DOI:10.1101/2021.06.01.21258172
Datei:https://doi.org/10.1101/2021.06.01.21258172
S. Trump, S. Lukassen, S. M. Anker, R. L. Chua, J. Liebig and e. a. Thurmann, "Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19", Nat Biotechnol, vol. 39, pp. 705—716, 2021.
DOI:10.1038/s41587-021-00937-2
C. Walsh, P. Tafforeau, W. Wagner and et al, "Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography", Nat Methods, vol. 18, no. 12, pp. 1532-1541, 2021.
DOI:10.1038/s41592-021-01317-x
J. Barros-Martins and et al, "Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination", Nature Medicine, vol. 27, pp. 1525—1529, 2021.
DOI:10.1038/s41591-021-01449-9
D. L. Burnett and et al, "Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability", Immunity, vol. 54, pp. 2908—2921.e6, 2021.
DOI:10.1016/j.immuni.2021.10.019
E. Schrezenmeier and et al, "Immunogenicity of COVID-19 Tozinameran Vaccination in Patients on Chronic Dialysis", Frontiers in immunology, vol. 12, pp. 690698, 2021.
DOI:10.3389/fimmu.2021.690698
K. F. Ahrens, R. J. Neumann, B. Kollmann, J. Brokelmann, N. M. Werthern, A. Malsyhau, D. Weichert, B. Lutz, C. J. Fiebach, M. Wessa and others, "Impact of COVID-19 lockdown on mental health in Germany: Longitudinal observation of different mental health trajectories and protective factors", Translational Psychiatry, vol. 11, no. 1, pp. 1—10, 2021.
DOI:10.1038/s41398-021-01508-2
B. Mühlemann and et al, "Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalised COVID-19 patients - results from a prospective observational study", Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2021.
DOI:10.1016/j.cmi.2021.06.008
B. Mühlemann, C. Thibeault, D. Hillus, E. Helbig, L. Lippert, P. Tober-Lau, T. Schwarz, M. Müller, P. group, M. Witzenrath and others, "Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study", Clin Microbiol Infect, 2021.
DOI:10.1016/j.cmi.2021.06.008
B. Mühlemann, C. Thibeault, D. Hillus, E. Helbig, L. Lippert, P. Tober-Lau, T. Schwarz, M. A. Müller, P. group, M. Witzenrath, N. Suttorp, L. E. Sander, C. Drosten, T. C. Jones, V. M. Corman and F. Kurth, "Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study. Clin Microbiol Infect. 2021;27(10)", 2021.
DOI:1520.e7-1520.e10
M. Ricke-Hoch, E. Stelling, L. Lasswitz, A. Gunesch, M. Kasten, F. Zapatero-Belinchón, G. Brogden, G. Gerold, T. Pietschmann, V. Montiel, J. Balligand, F. Facciotti, E. Hirsch, T. Gausepohl, H. Elbahesh, G. Rimmelzwaan, A. Höfer, M. Kühnel, D. Jonigk, J. Eigendorf, U. Tegtbur, L. Mink, M. Scherr, T. Illig, A. Schambach, T. Pfeffer, A. Hilfiker, A. Haverich and D. Hilfiker-Kleiner, "Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease", PLoS One, vol. 16, no. 8, pp. e0255335, Aug. 2021.
DOI:10.1371/journal.pone.0255335
N. Dauletbaev, S. Kuhn, S. Holtz, S. Waldmann, L. Niekrenz, B. S. Müller, C. Bellinghausen, M. Dreher, G. G. U. Rohde and C. Vogelmeier, "Implementation and use of mHealth home telemonitoring in adults with acute COVID-19 infection: A scoping review protocol", BMJ Open, vol. 11, no. 9, pp. e053819, 2021.
DOI:10.1136/bmjopen-2021-053819
A. Müller, F. S. Melzow, G. Göstemeyer, S. Paris and F. Schwendicke, "Implementation of COVID-19 Infection Control Measures by German Dentists: A Qualitative Study to Identify Enablers and Barriers", International Journal of Environmental Research and Public Health, vol. 18, no. 11, pp. 5710, 2021.
DOI:10.3390/ijerph18115710
V. Hennig and et al, "Increased risk of chronic fatigue and hair loss following COVID-19 in individuals with hypohidrotic ectodermal dysplasia", Orphanet Journal of Rare Diseases, vol. 16, pp. 373, 2021.
DOI:10.1186/s13023-021-02011-z
J. Weiner, P. Suwalski, M. Holtgrewe, A. Rakitko, C. Thibeault, M. Müller, D. Patriki, C. Quedenau, U. Krüger, V. Ilinsky, E. Helbig, L. Lippert, P. Stubbemann, X. Wang, Z. Karadeniz, J. Saccomanno, J. Doehn, R. Hübner, B. Hinzmann, S. Siemann, V. M. Corman, B. Mühlemann, C. Drosten, T. C. Jones, N. Suttorp, M. Witzenrath, S. Hippenstiel, C. Skurk, P. Group, L. E. Sander, D. Beule, U. Landmesser, T. Guettouche, F. Kurth, B. Heidecker, I. Popov, J. Balnis, A. Jaitovich, L. Real, J. Macías, J. Pineda, M. Fernandez-Fuertes, M. Salvo, A. Blueher, S. Jurisic, J. Beer, J. Rutishauser, B. Wiggli, H. Schmid, K. Danninger, R. Binder, R. Arjun Arkal, G. Fragiadakis, E. Mick, C. Comet, C. Calfee, D. Erle, C. Hendrickson, K. Kangelaris, M. Krummel, P. Woodruff, C. Langelier, U. Venkataramani, F. García, J. Zyla, B. Alice, T. Zemojtel, P. Wolfgang, T. Borodina and S. Ripke, "Increased risk of severe clinical course of COVID-19 in carriers of HLA-C", 04:01. EClinicalMedicine.2021;40:101099, 2021.
J. Weiner, P. Suwalski, M. Holtgrewe, A. Rakitko, C. Thibeault, M. Müller, D. Patriki, C. Quedenau, U. Krüger, V. Ilinsky and others, "Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01", EClinicalMedicine, 2021.
DOI:10.1016/j.eclinm.2021.101099
S. Dickel, C. Grimm, M. Popp, C. Struwe, A. Sachkova, M. Golinski, C. Seeber, F. Fichtner, D. Heise, P. Kranke, W. Meissner, S. Laudi, S. Voigt-Radloff, J. Meerpohl, J. Jabs, N. Mutters, O. Moerer and Group On Behalf Of The German CEOsys Study, "Infection control, prophylactic antibiotics, and testing for SARS-CoV-2 and PPE on German intensive care units: results from a national mixed methods survey", GMS Hyg Infect Control, vol. 16, pp. Doc21, 2021.
DOI:10.3205/dgkh000392
A. Köster, A. Bludau, S. Devcic and et al, "Infection surveillance measures during the COVID-19 pandemic in Germany", GMS Hyg Infect Control, vol. 16, 2021.
DOI:10.3205/dgkh000398
A. M. Köster, A. Bludau, S. K. Devcic, S. Scheithauer, A. A. Mardiko and R. Schaumann, "Infection surveillance measures during the COVID-19 pandemic in Germany", GMS hygiene and infection control, vol. 16, pp. Doc27, 2021.
DOI:10.3205/dgkh000398

Abstract:
Introduction: To address the question as to which infection surveillance measures are used during the ongoing COVID-19 pandemic in Germany and how they differ from pre-existing approaches. Methods: In accordance with the systematic approach of a scoping review, a literature search was conducted in national and international medical literature databases using a search string. The search in the databases was limited to the period from 01.01.2000 to 15.11.2020 and has been subsequently completed by hand search until 08.03.2021. A hand search, even beyond 15.11.2020, seemed necessary and reasonable, since due to the dynamics of the ongoing COVID-19 pandemic, a large number of articles and regulations are being published very quickly at short notice. Results: The literature search resulted in the following number of hits in the databases listed below: PubMed: 165 articlesCochrane: 1 review and 35 studiesWeb of Science: 217 articlesRobert Koch Institute: 49 articles Thus, a total of 467 hits were identified, with a total of 124 hits being duplicates. From these, 138 articles were considered relevant to the COVID-19 infection surveillance situation in Germany based on established criteria. After reading the full texts, 92 articles and websites were ultimately included in the scoping review. Discussion: Many of the lessons learned from previous outbreaks seem to have been implemented in the infection surveillance measures during the ongoing COVID-19 pandemic in Germany. Most of the changes compared with previous measures were based on technological streamlining of existing procedures and changes and more inclusion of the population in different infection surveillance measures. Einleitung: Es wird der Frage nachgegangen, welche Maßnahmen zur Infektionsüberwachung während der aktuellen COVID-19-Pandemie in Deutschland eingesetzt werden und wie sie sich von bereits bestehenden Ansätzen unterscheiden.Methoden: Entsprechend der systematischen Vorgehensweise eines Scoping Reviews wird eine Literaturrecherche in nationalen und internationalen medizinischen Literaturdatenbanken mittels Suchstring durchgeführt. Die Suche in den Datenbanken ist auf den Zeitraum vom 01.01.2000 bis zum 15.11.2020 begrenzt und anschließend per Handsuche bis zum 08.03.2021 ergänzt. Eine Handsuche, auch über den 15.11.2020 hinaus, erscheint notwendig und sinnvoll, da aufgrund der Dynamik der laufenden COVID-19-Pandemie sehr kurzfristig eine große Anzahl von Artikeln und Verordnungen veröffentlicht werden.Ergebnisse: Die Literaturrecherche hat die folgende Anzahl von Treffern in den unten aufgeführten Datenbanken ergeben: PubMed: 165 ArtikelCochrane: 1 Review und 35 StudienWeb of Science: 217 ArtikelRobert Koch-Institut: 49 Artikel Somit sind insgesamt 467 Treffer identifiziert worden, wobei insgesamt 124 Treffer Duplikate sind. Anhand festgelegter Kriterien werden 138 Artikel als relevant für die COVID-19-Infektionssurveillance in Deutschland eingestuft, und nach dem Lesen der Volltexte schließlich 92 Artikel und Webseiten in den Scoping Review aufgenommen.Diskussion: Viele der Maßnahmen, die aufgrund früherer Ausbruchsgeschehen bekannt sind, scheinen auch bei der jetzigen Infektionsüberwachung während der laufenden COVID-19-Pandemie in Deutschland umgesetzt worden zu sein. Die meisten Änderungen im Vergleich zu früheren Maßnahmen betreffen technologische Neuerungen sowie eine stärkere Einbeziehung der Bevölkerung in die verschiedenen Maßnahmen zur Infektionsüberwachung.
E. Wyler, J. M. Adler, K. Eschke, G. T. Alves, S. Peidli and e. a. Pott, "Insights into standards of care – dexamethasone and antibodies against COVID-19 in hamster models", bioRxiv, 2021.
DOI:10.1101/2021.12.17.473180
T. Houwaart, S. Belhaj, E. Tawalbeh and et al, "Integrated Genomic Surveillance reveals extensive onward transmission of travel-imported SARS-CoV-2 infections in the community", MedRxiv, 2021.
DOI:10.1101/2021.10.18.21264530
S. Schroeder, F. Pott, D. Niemeyer, T. Veith, A. Richter and e. a. Muth, "Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics", Lancet Microbe, vol. 2, pp. e210—e218, 2021.
DOI:10.1016/S2666-5247(21)00069-0
J. Burns, A. Movsisyan, J. Stratil, R. Biallis, M. Coenen, K. Emmert-Fees, K. Geffert, S. Hoffmann, O. Horstick, M. Laxy, C. Klinger, S. Kratzer, T. Litwin, S. Norris, L. Pfadenhauer, P. Philipsborn, K. Sell, B. Stadelmaier, S. Voss, K. Wabnitz and E. Rehfuess, "International travel-related control measures to contain the COVID-19 pandemic: a rapid review", Cochrane Database of Systematic Reviews, vol. 3, 2021.
DOI:10.1002/14651858.CD013717.pub2
S. Strobl and W. Roth, "Internationale wissenschaftliche Publikationsaktivität zu COVID-19 [International publication activity during the COVID-19 pandemic]", Pathologe, vol. 42, no. 2, pp. 224-230, 2021.
M. Andreas, V. Piechotta, N. Skoetz, K. Grummich, M. Becker, L. Joos, G. Becker, W. Meissner and C. Boehlke, "Interventions for palliative symptom control in COVID-19 patients", Cochrane Database of Systematic Reviews, vol. 2021, no. 8, pp. CD015061, 2021.
DOI:10.1002/14651858.CD015061
M. Andreas, V. Piechotta, N. Skoetz, K. Grummich, M. Becker, S. Joos, G. Becker, W. Meissner and C. Boehlke, "Interventions for palliative symptom control in COVID-19 patients", Cochrane Database of Systematic Reviews, pp. CD015061, 2021.
DOI:10.1002/14651858.CD015061.pub2
S. Halwe and et al, "Intranasal Administration of a Monoclonal Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection", Viruses, vol. 13, 2021.
DOI:10.3390/v13081498
S. Halwe, A. Kupke, K. Vanshylla and et al, "Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection", Viruses, vol. 13, no. 8, 2021.
DOI:10.3390/v13081498
Datei:https://doi.org/10.3390/v13081498
B. Bošnjak, I. Odak, J. Barros-Martins and et al, "Intranasal delivery of MVA vector vaccine induces effective pulmonary immunity against SARS-CoV-2 in rodents", Front Immunol, vol. 12, 2021.
DOI:10.3389/fimmu.2021.772240
Datei:https://doi.org/10.3389/fimmu.2021.772240
B. Bošnjak and et al, "Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in Rodents", Frontiers in Immunology, vol. 12, pp. 772240, 2021.
DOI:10.3389/fimmu.2021.772240
M. Popp, M. Stegemann, M. Metzendorf, S. Gould, P. Kranke, P. Meybohm, N. Skoetz and S. Weibel, "Ivermectin for preventing and treating COVID‐19", Cochrane Database of Systematic Reviews, vol. 2021, pp. CD015017, 2021.
DOI:10.1002/14651858.CD015017.pub2
J. J. Malin, C. D. Spinner, U. Janssens, T. Welte, S. Weber-Carstens, G. Schälte, P. Gastmeier, F. Langer, M. Wepler, M. Westhoff, M. Pfeifer, K. F. Rabe, F. Hoffmann, B. W. Böttiger, J. Weinmann-Menke, A. Kersten, P. Berlit, M. Krawczyk, W. Nehls, F. Fichtner, S. Laudi, M. Stegemann, N. Skoetz, M. Nothacker, G. Marx, C. Karagiannidis and S. Kluge, "Key summary of German national treatment guidance for hospitalized COVID-19 patients Key pharmacologic recommendations from a national German living guideline using an Evidence to Decision Framework (last updated 17.05.2021)", Infection, 2021.
DOI:10.1007/s15010-021-01645-2
K. Vanshylla and et al, "Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans", Cell host & microbe, 2021.
DOI:10.1016/j.chom.2021.04.015
M. Schmidt, C. Löwe, S. Kugai, A. Thielmann and B. Weltermann, "Kommunikations- und Kooperationsstrukturen von Hausärzt*innen und Gesundheitsämtern – Erkenntnisse der egePan-Studie", DocV-22-02, 2021.
DOI:10.3205/21degam120
S. Stillfried, T. Acker, M. Aepfelbacher, G. Baretton, R. D. Bülow, K. F. Bürrig, U. H. Holtherm, D. Jonigk, R. Knüchel, R. W. Majeed, R. Röhrig, J. Wienströer and P. Boor, "Kooperatives Vorgehen der Pathologie und Neuropathologie in der COVID-19-Pandemie : Deutsches Register für COVID-19-Obduktionen (DeRegCOVID) und Deutsches Netzwerk für Autopsien in Pandemien (DEFEAT PANDEMIcs) [Cooperative approach of pathology and neuropathology in the COVID-19 pandemic : German registry for COVID-19 autopsies (DeRegCOVID) and German network for autopsies in pandemics (DEFEAT PANDEMIcs)]", Pathologe, vol. 42, no. 2, pp. 216-223, 2021.
K. U. Ludwig, R. M. Schmithausen, D. Li and et al, "LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding", Nat Biotechnol, vol. 39, no. 12, 2021.
DOI:10.1038/s41587-021-00966-9
Datei:https://doi.org/10.1038/s41587-021-00966-9
C. N. Englisch, T. Tschernig, F. Flockerzi, C. Meier and R. M. Bohle, "Lesions in the lungs of fatal coronavirus disease COVID-19", Ann Anat, vol. 234, pp. 151657, 2021.
DOI:10.1016/j.aanat.2020.151657
S. J. Theobald and et al, "Long-lived macrophage reprogramming drives spike protein–mediated inflammasome activation in COVID–19", EMBO Mol Med, 2021.
DOI:10.15252/emmm.202114150
P. Knolle, N. Körber, A. Priller and et al, "Long-term follow-up of SARS-CoV-2 convalescents reveals distinct magnitude of spike-specific immunity after viral re-exposure and vaccination", Research Square, 2021.
DOI:10.21203/rs.3.rs-677167/v1
A. Horn, L. Krist, W. Lieb, F. Montellano, M. Kohls, K. Haas, G. Gelbrich, S. Bolay-Gehrig, C. Morbach, J. Reese and others, "Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP)", Infection, vol. 49, no. 6, pp. 1277—1287, 2021.
DOI:10.1007/s15010-021-01707-5
A. Horn, L. Krist, W. Lieb, F. Montellano, M. Kohls, K. Haas, G. Gelbrich, S. Bolay-Gehrig, C. Morbach, J. Reese, S. Störk, J. Fricke, T. Zoller, P. Triller, L. Kretzler, M. Rönnefarth, C. Kalle, F. Kurth, F. Steinbeis, M. Witzenrath, T. Bahmer, A. Hermes, M. Krawczak, L. Reinke, C. Maetzler, J. Franzenburg, J. J. Vehreschild, M. Schons, T. Illig, G. Anton, K. Ungethüm, P. Heuschmann, T. Keil and S. Schreiber, "Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP)", Infection. 2021;49(6):1277-87. IF: 3.553, 2021.
A. Horn, L. Krist, W. Lieb, F. Montellano, M. Kohls, K. Haas, G. Gelbrich, S. Bolay-Gehrig, C. Morbach, J. Reese, S. Störk, J. Fricke, T. Zoller, S. Schmidt, P. Triller, L. Kretzler, M. Rönnefarth, C. Kalle, S. Willlich, F. Kurth, F. Steinbeis, M. Witzenrath, T. Bahmer, A. Hermes, M. Krawczak, L. Reinke, C. Maetzler, J. Franzenburg, J. J. Vehreschild, M. Schons, T. Illig, G. Anton, K. Ungethüm, P. Heuschmann, T. Keil, S. Schreiber, S. Schmidt, S. N. Willich, J. Enderle, A. Flinspach, B. C. Finkenberg, M. T. Gehrig and N. Savaskan, "Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP).", Infection. 2021;49(6):1277-87. IF: 3.553, 2021.
P. Tober-Lau and et al, "Long-term immunogenicity of BNT162b2 vaccination in older people and younger health-care workers", The Lancet Respiratory Medicine, vol. 9, pp. e104-e105, 2021.
DOI:10.1016/S2213-2600(21)00456-2
M. Jan\'ıková, J. Hodosy, P. Boor, B. Klempa and P. Celec, "Loop-mediated isothermal amplification for the detection of SARS-CoV-2 in saliva", Microb Biotechnol, vol. 14, no. 1, pp. 307-316, 2021.
DOI:10.1111/1751-7915.13737
S. Contreras, J. Dehning, S. B. Mohr, S. Bauer, F. P. Spitzner and V. Priesemann, "Low case numbers enable long-term stable pandemic control without lockdowns", Science advances, vol. 7, no. 41, pp. eabg2243, 2021.
DOI:10.1126/sciadv.abg2243
E. Kuhlmann, S. Heinemann, A. Bludau and et al, "Managing protection and surveillance of health workers during COVID-19: German multi-centre survey", Eur J Public Health, vol. 31, no. Supplement 3, 2021.
DOI:10.1093/eurpub/ckab165.441
M. Holfelder and et al, "Medical Device Regulation Efforts for mHealth Apps during the COVID-19 Pandemic—An Experience Report of Corona Check and Corona Health", J, vol. 4, pp. 206—222, 2021.
DOI:10.3390/j4020014
C. Bartels, P. Hessmann, U. Schmidt, J. Vogelgsang, M. Ruhleder, A. Kratzenberg, M. Treptow, T. Reh-Bergen, M. Abdel-Hamid, L. Heß, M. Meiser, J. Signerski-Krieger, K. Radenbach, S. Trost, B. H. Schott, J. Wiltfang, C. Wolff-Menzler and M. Belz, "Medium-term and peri-lockdown course of psychosocial burden during the ongoing COVID-19 pandemic: A longitudinal study on patients with pre-existing mental disorders", European Archives of Psychiatry and Clinical Neuroscience, 2021.
DOI:10.1007/s00406-021-01351-y