The NSN builds on the preliminary work of the National Pandemic Cohort Network (NAPKON), the NUM Clinical Epidemiology and Study Platform (NUKLEUS) and the NUM Data Integration Centres (NUM-DIZ). These established concepts and resulting infrastructures, organisational units and empirical values serve as the basis for a gradually growing, efficient network for the efficient implementation of clinical and clinical-epidemiological studies in Germany and will be rolled out uniformly among the participating network partners.